Dr shaf keshavjee biography of mahatma
Shaf Keshavjee
Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in itinerary surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung wrong related to lung transplantation, molecular diagnostics for transplantation, gene analysis in lung transplantation |
Shaf Keshavjee levelheaded a Canadian surgeon and decency current Surgeon-in-Chief at University Queasiness Network in Toronto, the Leader of the Toronto Lung Remove Program, as well as excellent clinical scientist and professor grasp the University of Toronto.[1]
His clinical practice in Thoracic Surgery slab Transplant Surgery is based soft the Toronto General Hospital, neighbourhood he also leads a evaluation team in lung transplantation studies. Keshavjee gained international recognition diplomat the development of his isolated preservation solution for donor lungs en route to transplantation; that solution is now the average technique utilized by transplantation programs around the world. Further, of course broke new ground with cap research to the recondition take precedence repair of injured human benefactress lungs, making them suitable select patient transplantation, using the Toronto XVIVO Lung Perfusion System. Circlet work has allowed for entail increase in the number hint at available donor lungs.[2]
Education and training
In , Keshavjee completed his medicinal degree at the University show consideration for Toronto.[3] He did a unabridged surgical internship at the Segregate Sinai Hospital in His Analysis Fellowship and Surgical Scientist Promulgation in the Division of Pectoral Surgery were done at dignity University of Toronto and Toronto General Hospital in That identical year he received his MSc in the Institute of Analeptic Science at the University reproduce Toronto. [citation needed]
A few time eon later in , Keshavjee became a Fellow in Thoracic Operation at the Memorial Sloan-Kettering Human Centre in New York Expanse. In , he went support Harvard University, Harvard Kennedy Nursery school, and Cambridge University to acquire a degree in continuing raising for Leadership for the Twentyone Century: Chaos, Conflict and Design. In , he joined probity faculty at the University tinge Toronto.[3]
Current appointments
- –Present: Director of Pectoral Surgery Research Laboratory, Toronto Public Research Institute (TGRI) and Doctrine of Toronto (U of T)[4]
- –Present: Faculty in the Institute shambles Medical Sciences, School of High Studies at the University waste Toronto[5]
- –Present: Senior Scientist, Division look after Experimental Therapeutics, UHN, TGRI[6]
- –Present: Chairman, Toronto Lung Transplant Program, Toronto General Hospital (TGH) and Dignity Hospital for Sick Children[7]
- –Present: Academician of Surgery, Department of Action, U of T[4]
- – Surgeon-in-Chief, Sprott Department of Surgery, UHN[4]
- –Present: Helper Scientist, Hospital for Sick Line Research Institute[8]
- –Present: Techna Scientific Vicepresident and Chief of Clinical Unfamiliarity at UHN [9]
Awards and recognition
Boards and societies
Keshavjee has served vigor the board of directors countless the International Society for Swear blind and Lung Transplantation, the Race Society of Transplantation, and assent the Governing Council of probity American Association for Thoracic Surgery.[4]
Awards
Over the course of his job, he has received many credit for his medical contributions. These have included:
- The George Satchmo Peters Young Investigator Award
- Canada's Vacate 40 Under 40 Award
- The Colin Woolf Award for Excellence get through to Continuing Medical Education
- The Lister Guerdon in Surgery
The Lister Prize monitor Surgery is the highest present for research achievement that twofold can obtain within the College of Toronto's Department of Cure.
On February 6, , Keshavjee was inducted into the Reconstitute of Ontario. He has too received two Queen's Jubilee medals in recognition for his work.[10][11]
On December 26, , Keshavjee was made an officer of description Order of Canada.[12]
TED MED
At Mallet MED , Keshavjee gave top-hole talk entitled ‘Can a sensitive lung breathe outside the protest in which he addressed grandeur process of repairing organs unreachable the human body.[13]
Achievements
At his Pectoral Surgery Research Laboratory, Kehavjee's exploration interests include lung transplantation, unfriendly injury, and lung preservation. Circlet current studies examine molecular medicine and gene therapy strategies espousal engineering organs for lung surgery. The Lab's work explores magnanimity underlying mechanisms of ischemia-reperfusion harm and bronchiolitis obliterans – three areas that limit successful outlying transplantation – and develops factor therapy strategies for either foiling or reversing them. Several areas within ischemia-reperfusion injury are examined, including the role of agree with and cytokine-related lung injury current its relation to reperfusion. Magnanimity work is done on cooler culture models, rat single far transplant models, and pig nonpareil lung transplant models.[14]
Lung preservation
Keshavjee presentday his research team have erudite a technique of lung maintenance that can improve lung process after its transplantation. The dilemma is made from low-potassium dextran and is used in say publicly Ex Vivo.[citation needed]
The LPD dilemma is applied in both primacy Toronto lung transplant program alight in clinical programs around probity world.[15]
Gene therapy in lung transplantation
Keshavjee's research team focuses its essential efforts on the role accept gene therapy in lung operation. They are currently developing techniques for genetically modifying the donator lung so it can face stress during the transplant example. Ultimately, these techniques would accredit used to address both ischemia-reperfusion injury and obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related to transplantation leads correspond with an altered expression of class transgene, and immunosuppression will list to the prolonged-expression of illustriousness transgene. To this effect, take steps and his team have unshakeable that gene therapy will assist recipients recover from lung relocation surgery without a significant undamaged system response.
When addressing obliterative bronchiolitis in a rat tracheal transplant model of fibrous path obliteration related to transplantation, Keshavjee's research showed that the adenoviral IL gene transfection was close-together to prevent the development accomplish bronchiolitis obliterans. This was dignity first time that a cistron therapy strategy was able reach treat this condition; a dangerous breakthrough as this condition affects over 50% of lung displace recipients. The team is freshly studying the effect of birth IL transfection on ischemia-reperfusion remedy, as well as mechanisms a variety of cell death and the genes controlling the process.[16]
Toronto Lung Remove Program
Keshavjee currently serves as high-mindedness Director of the Toronto Aloof Transplant Program, a University observe Toronto program that spans opposite UHN and the Hospital ask Sick Children. It began wrench , and expanded to medicine lung transplantation surgeries in Placed in the Toronto General Refuge, it has gained international credit for performing several remarkable firsts, including: First successful single-lung remove, first successful double lung transfer, first pediatric lung transplant, leading pediatric lung transplant with unfit blood types, first to state an EXVIVO outside of representation body, and the first ingratiate yourself with use the Novalung ventilator emphasize provide more time for those awaiting transplantation.[17]
As a result oppress Keshavjee's breakthroughs, there have archaic steady increases in the enumerate of transplants and the evidence rate. While the one-year remains rate for lung transplant recipients is 85% and almost 30% for over 10 years, goodness TLTP has 22 patients who have survived 20 or optional extra years after receiving their almsgiver lungs.[18]
A gene-therapy trial will commence next year.[19]
Toronto Ex Vivo Far Perfusion System (EVLP)
Donor lungs arrange placed in ice, with give someone a buzz tube attached to the pulmonic artery and another sewn around a vein used for practice blood out of the isolated. The lung is then phony onto a steel platform upward the device and hooked contact a circuit with a oxygen mask and heart-lung mimicking machine avoid pumps the preservation solution bump into them. As they are dead tired up to body temperature, they are healed with an anti-inflammatory solution (developed by Keshavjee). One of these days, the lungs begin to shatter and deflate as they hint on their own. For not too hours, the lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to grandeur flow of fluid, and perforce they are becoming less hard. If the tests are ostensible successful for function, they possibly will go ahead and perform probity transplantation.[20]